Leveraging high-valent organohalogen for C–H coupling and molecular design

发布时间:2024-09-23 浏览次数:10

时间:9月23日(周一)10:00-11:00

地点:16幢一楼路演厅

主讲人:Alexandr Shafir

Alexandr Shafir graduated in Chemistry from Hunter College (New York). In 2003, he obtained his PhD in organometallic chemistry from UC Berkeley (USA) under the supervision of John Arnold, with a project involving poly-metallic coordination complexes based on diaminoferrocene. His subsequent postdoctoral stay took place in the Stephen Buchwald laboratory at MIT, where he worked on new catalysts for Cu-catalyzed C-N and C-O bond forming reaction, and, in the process, got a full appreciation of the potential offered by modern organic Method Development. Thanks to the funding through the Ramón y Cajal program, in 2007 he moved to the Universitat Autònoma de Barcelona, where he began work on hypervalent iodine reagents, initially applying them to selective oxidative cross-coupling coupling of unactivated arenes.  Between 2013-2018, Shafir was a Junior Group Leader at the Institut Català d’Investigació Química (ICIQ) in Tarragona. During this time, he established the Synthetic and Mechanistic Research laboratory, which focused on catalysis, MOF-type porous materials, and, once again, oxidative CH functionalization reactions, particularly through the use of hypervalent iodine reagents. To continue this program, in 2018 he was appointed Cientifico Titular (Tenured Scientist) of CSIC at the IQAC institute in Barcelona. Jointly with prof. A. B. Cuenca, he co-founded the BISI Bonds research group, which is currently active in developing new classes of carbon-carbon and carbon-heteroatom bond-forming reaction by combining catalysis and main group chemistry. In particular, over the years the group has been recognized for its contributions to our understanding of the structure and reactivity of high valent iodine reagents, and their applications to modern organic synthesis. Shafir is currently the vice-president of the Catalan section of Spain’s RSEQ (chemical) society.


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